Gut Microbiota, microRNA
Conditions
Keywords
stachyose, gut microbiota, microRNA
Brief summary
In this study, stachyose was used as an intervention factor. We will evaluate changes in fecal gut microbiota and miRNA expression profiles in subjects under stachyose intervention
Detailed description
In the stachyose intervention group, each person in the stachyose intervention group took 5 g of stachyose daily before breakfast, and the administration method was 100 ml of drinking water dissolved and taken orally for two months. Each person in the placebo control group took the same amount of maltodextrin daily. Stool samples of the subjects were collected weekly.
Interventions
DIETARY_SUPPLEMENTstachyose
Stachyose is a tetrasaccharide consisting of sucrose having an alpha-D-galactosyl-(1-\>6)-alpha-D-galactosyl moiety attached at the 6-position of the glucose.
DIETARY_SUPPLEMENTMaltodextrin
Maltodextrin is a polysaccharide that is used primarily in foods and beverages as a thickener, sweetener, and/or stabilizer. It is a relatively short-chain polymer (some would call it an oligomer); commercial products contain an average of ≈3 to ≈17 glucose units per chain. It is manufactured by partially hydrolyzing grain starches, usually corn or wheat.
Sponsors
Xijing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy human
Exclusion criteria
* people who need intake antibiotics，probiotics or its product
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| expression of microRNA | up to 4 weeks | small rna sequencing valuated the microRNA expression in human |
| structure of gut microbiota | up to 4 weeks | 16S rDNA sequencing valuated the gut microbiota composition in human |
Countries
China
Contacts
Primary ContactChao Guo
Outcome results
None listed