Gestational Diabetes
Conditions
Brief summary
The investigators aimed to determine the predictive values of fetal pancreas size and maternal serum biomarkers glycated albumin (GA) and insulin-regulated aminopeptidase (IRAP) for gestational diabetes mellitus (GDM).
Detailed description
The investigators aimed to determine the predictive values of fetal pancreas size and maternal serum biomarkers glycated albumin (GA) and insulin-regulated aminopeptidase (IRAP) for gestational diabetes mellitus (GDM).In this prospective observational study including 109 pregnant women, the fetal pancreas size and maternal serum biomarkers GA and IRAP were measured at the gestational age of 20-22 weeks and later at the gestational age of 24-28 weeks, in 19 participants of them, GDM was confirmed with the 75-g oral glucose tolerance test (OGTT) and the fetal pancreas size was measured in all the participants again.
Interventions
None listed
Sponsors
Haseki Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* Maternal age between 18 and 42 years * Gestational age between 20 and 28 weeks
Exclusion criteria
* Multiple pregnancies * Pregestational diabetes * Fetal congenital malformations * Placental and amniotic fluid abnormalities * Preeclampsia * Severe systemic disease * Long-term systemic drug usage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early prediction of gestational diabetes | Two months | Early prediction of gestational diabetes by the fetal pancreas measurement with ultrasound and maternal serum biomarkers glycated albumin and insulin-regulated aminopeptidase measured with ELISA |
Countries
Turkey (Türkiye)
Outcome results
None listed