Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05392062

Acronym

COVAQ

Enrollment

Registered

2022-05-26

Start date

2021-06-09

Completion date

2023-04-15

Last updated

2024-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Insufficiency

Keywords

Gas exchange, COVID-19, acute respiratory distress syndrome, spontaneous breathing, Respiratory failure

Brief summary

The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.

Interventions

OTHERPathophysiology of gas exchange

Exploration of pathophysiology of gas exchange

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

: * Patients with a COVID-19 confirmed infection. * Admission in intensive care unit for an acute respiratory failure requiring oxygen flow above 6l/min by facial mask. * Presence of an arterial catheter for blood sampling.

Exclusion criteria

: * Patients on mechanical ventilation on admission to the ICU. * Patients requiring immediate intubation on admission. * Patients admitted to the ICU for more than 48 hours at the time of inclusion. * Pulmonary embolism diagnosed before admission to the ICU. * Minor patients * Pregnant women * Patients under curatorship or guardianship * Persons deprived of liberty by a judicial or administrative decision

Design outcomes

Primary

Measure	Time frame	Description
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and need to intubation.	Lenght of hospital stay in intensive care unit	From date of admission in intensive care unit (ICU) until the date of death or disharge from ICU, assessed up to 90 days

Secondary

Measure	Time frame	Description
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D90.	Day 90	No provided
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D28.	Day 28	No provided
Association between intrapulmonary right-to-left shunt, ventilatory ratio with percentage of lung damage on chest CT-scan.	At admission	No provided

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026