Multiple Sclerosis
Conditions
Brief summary
Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI). In this study, the investigators evaluate the use of IVIM in patients with Multiple Sclerosis.
Detailed description
Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI), it is achieved through an MRI acquisition with multiple small b value to extract perfusion data. It has been shown to be a promising technique in evaluation of many brain conditions. This study seeks to assess intravoxel incoherent motion (IVIM) parameters in characterizing plaques and specific tissues in multiple sclerosis.
Interventions
OTHERDiffusion-weighted magnetic resonance imaging
Diffusion-weighted magnetic resonance imaging
Sponsors
Chinese University of Hong Kong
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Patients who are 18 years or older. 2. Relapsing-remitting MS diagnosed as per Macdonald criteria
Exclusion criteria
1. Contraindication to MRI. For example, metal implantation in the body, claustrophobia and pregnancy. 2. Patients who are unable to tolerate the scans without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IVIM parameters (including ADC,D,D*,f) in Multiple Sclerosis brain regions. | Up to 2 months | Primary Outcome Measure: 1\. IVIM parameters (including ADC,D,D\*,f) in Multiple Sclerosis brain regions. The parameters are calculated based on a IVIM model bi-exponential model represented by: S(b)/S(0)=f ×exp(-bD\*)+ (1-f)×exp(-bD), and the mono-exponential model for ADC calculation as represented by: S(b)/S(0)=exp(-bADC), where S(b) and S (0) are the MRI signal intensities at a given b value and b = 0, respectively. ADC: apparent diffusion coefficient. ADC is expressed in units of mm2/s. f: the perfusion or (micro) vascular volume fraction which depends on capillary geometry and blood velocity. f is expressed in units of mm2/s. D\*: pseudo diffusion coefficient that resembles the perfusion related incoherent microcirculation. D\* is expressed in units of mm2/s. D: pure diffusion coefficient which is related to pure molecular diffusion. D is expressed in units of mm2/s. |
Countries
Hong Kong
Outcome results
None listed