Coronary Artery Disease, Heart Failure, Resistance Training
Conditions
Keywords
Cardiac rehabilition, exercise therapy, metabolic stress
Brief summary
The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population. 3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of \ 70% of one repetition maximal (1RM). Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes. The investigators collect blood sample before exercice, after HIIT and after RT. It is randomized cross-over study.
Detailed description
The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study. The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.
Interventions
OTHERCardiac rehabilitation with 3/7 method
HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.
OTHERCardiac rehabilitation with 3X9 method
HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned
Sponsors
Université Libre de Bruxelles
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical Coronary artery diseases * Heart failure with reduced ejection fraction
Exclusion criteria
* angina * acutely decompensated heart failure * electrocardiographic evidence of ischemia * significant valvular disease * orthopedic/neurologic disorders that limited exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Lactate | within 2 minutes after TR training session on day 1 | mmol/l |
| change in Testosterone | within 2 minutes after TR training session on day 1 | nmol/l |
| change Glucocorticoid Cortisol | within 2 minutes after TR training session on day 1 | nmol/l |
| change in ph | within 2 minutes after TR training session on day 1 | venoust |
| change PCO2 venoust | within 2 minutes after TR training session on day 1 | mm Hg |
| change in Growth Hormone | within 2 minutes after TR training session on day 1 | ng/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Borg scale | within 4 minutes after TR training session on day 1 | Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion) |
| Pleasure of the session scale | within 4 minutes after TR training session on day 1 | 0 = worse 10 = better |
Countries
Belgium
Outcome results
None listed