Autism Spectrum Disorder
Conditions
Keywords
Autism; MRI;Addictive disorders
Brief summary
An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.
Detailed description
An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers, where pathophysiology common to both disorders, based on a dysfunction of the reward system. The project we propose aims to explore the neural networks underlying these alterations in patients suffering from autism or addictive disorder.
Interventions
DIAGNOSTIC_TESTMRI
an fMRI measurement of the BOLD physiological signal for sensory responses
DIAGNOSTIC_TESTEEG
These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.
Sponsors
INSERM UMR-1253, Tours, France
University Hospital, Tours
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Pilot study, monocentric open in three parallel groups (ASD, AD and healthy volunteers).
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria) Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES \>= 18 criteria). Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk. For all participants: * Age greater than or equal to 18 years old * Without intellectual delay (IQ \> 70). * Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator. * Free, express, informed and written consent of the participant. * Participant affiliated to a social security scheme
Exclusion criteria
* Neuromotor disorders. * Visual disturbances not corrected or incompatible with MRI. * Known epilepsy. * Current substance use disorder with emotional distress/significant impact on functional outcome * Rare genetic syndrome. * Contraindications to MRI (other than body circumference) * For women of childbearing age: negative urine or blood pregnancy test * Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Oxygene Level Dependent (BOLD) MRI signal | At inclusion | Measurement in fMRI of the BOLD signal for each condition (interest, addiction, social) will be carried out in order to highlight the possible alterations of the reward system, in particular at the level of the striatum in terms of cerebral activation for each of the groups of subjects. (FAD, ASD and HV). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tolerance to an MRI examination for FAD with overweight or obesity | At inclusion | For the tolerance to an MRI examination for FAD with overweight or obesity: feedback on their experience in MRI. |
| Regulation of sensory, an fMRI measurement of the BOLD physiological signal for sensory responses (sensory block) in terms of brain activation in patients | At inclusion | Regulation of sensory, an fMRI measurement of the BOLD physiological signal for sensory responses (sensory block) in terms of brain activation in patients with FAD compared to ASD subjects and healthy volunteers. |
Countries
France
Contacts
Primary ContactFrédéric BRIEND, PhD
Backup ContactCoralie TAILLEBUIS, MSc
Outcome results
None listed