Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

Association Between Preoperative Level of Hemoglobin A1c and the Incidence of Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery: a Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05390281

Enrollment

Registered

2022-05-25

Start date

2019-06-01

Completion date

2020-10-01

Last updated

2025-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Brief summary

Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

Interventions

DIAGNOSTIC_TESTincrease in serum creatinine

any of the following: increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA physical status II-III * scheduled to undergo isolated coronary artery bypass grafting

Exclusion criteria

* Patients with history of renal failure * Patients with history of hepatic failure * Patients with history of heart failure * previous cardiac surgery * cerebrovascular event in the last 30 days * percutaneous coronary intervention in the last 30 days prior to operation * peripheral arterial disease * malignancy * infectious diseases * patients who required surgical revision * patients who required postoperative intra-aortic balloon pump * patients with CBP time \> 120 min or aortic cross clamp time \> 90 min

Design outcomes

Primary

Measure	Time frame	Description
serum creatinine level	3 days	increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinine to ≥ 1.5 times baseline within 3 days of cardiac surgery

Secondary

Measure	Time frame	Description
Patients in need of RRT	7 days	The number of patients requiring postoperative renal replacement therapy

Other

Measure	Time frame	Description
Length of ICU stay	7days	The duration of postoperative patient stay in the intensive care

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026