Kidney Stone
Conditions
Brief summary
To define the effect of crystal light, potassium citrate, or both on urinary stone risk factors in patients with a history of stone and hypocitraturia/low pH
Interventions
7 days potassium citrate followed by 24 hour urine collection
DRUGCrystal light
7 days crystal light followed by 24 hour urine collection
DRUGPotassium citrate + crystal light
7 days potassium citrate + crystal light followed by 24 hour urine collection
Sponsors
Northwestern University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Men and women between age 18-80 years 2. Willing to follow experimental protocol 3. Willing to complete 24-hour urine collections (three total) 4. Willing to sign the informed consent form 5. Completed Litholink Collection with blood work with results a. hypocitraturia OR aciduria i. Hypocitraturics must meet definition of \< 450 mg/day for men \< 550 mg/day for women. b. Low urine pH must be less than 5.6 c. potassium, BUN, creatinine, eGFR and hemoglobin A1c within normal limits
Exclusion criteria
1. Patients with severe hypocitraturia \< 200 mg/day (men or women) 2. Patients with hyperkalemia, uncontrolled diabetes, chronic kidney disease, adrenal insufficiency, delayed gastric emptying (or drug induced delayed gastric emptying), peptic ulcer disease, or active UTI 3. Patients with distal renal tubular acidosis or medication induced RTA (e.g. carbonic anhydrase inhibitor, topiramate) 4. Members of vulnerable patient populations 5. Allergies to ingredients in crystal light 6. Patients lacking decisional capacity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| urine citrate levels | Day 7 of week 1 | 24 hour urine collection |
Countries
United States
Outcome results
None listed