Cirrhosis, Frailty, Kidney Injury, Sarcopenia
Conditions
Brief summary
The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.
Detailed description
The aim of this prospective study is to collect data on patients with liver cirrhosis and to investigate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis. If patients agree to participate in this clinical trial, the patients' data (such as age, sex, height, weight, nutrition status \[RFH-NPT\], history of medication, laboratory findings, endoscopic findings, and radiologic findings) will be collected in a research database. Renal injury was measured using conventional and novel serum biomarkers (serum creatinine, cystatin-C, neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, and interleukin-18. Sarcopenia was evaluated using skeletal muscle index on abdominal computed tomography. Frailty was measured using Liver Frailty Index. The research database will be updated to include data on patients' disease outcomes and follow-up care.
Interventions
None listed
Sponsors
Kangbuk Samsung Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Liver cirrhosis * aged over 20 years
Exclusion criteria
* serum creatinine \>1.5 mg/dL * on dialysis * liver transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Acute kidney injury | up to 24 weeks | an increase in SCr of 0.3 mg/dL (26.4 µmoL/L) in \<48 hours, or a 50% increase in SCr from a baseline within ≤3 months |
Countries
South Korea
Outcome results
None listed