COVID-19, Multiple Sclerosis
Conditions
Brief summary
The Radiologically Isolated Syndrome (RIS) is defined as incidental Magnetic Resonance Imaging (MRI) abnormalities fulfil the criteria for dissemination in space, suggestive of multiple sclerosis. Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. We aimed to evaluate if COVID19 vaccination or infection increased the risk of clinical conversion to multiple sclerosis or evidence of disease activity (EDA) in a cohort of RIS subjects.
Interventions
OTHERNO intervention
no intervention
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients belong to the RISC cohort; * totally vaccinated ou partially vaccinated patient * vaccination status known
Exclusion criteria
* presented a first clinical event before the COVID19 vaccination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| COVID 19 vaccination and clinical conversion to multiple sclerosis risk | year 2 | number of patients with a conversion to MS in each group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| COVID 19 vaccination and evidence disease activity risk | year 2 | number of patients with an evidence disease activity in each group |
| multiple sclerosis evolution and history of COVID 19 infection | year 2 | number of patients with a conversion to MS in each group |
Countries
France
Outcome results
None listed