Acute Kidney Injury, Extracorporeal Circulation; Complications, Surgery
Conditions
Brief summary
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.
Detailed description
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. The incidence of cardiac surgery-associated AKI (CSA-AKI) varies from 5% to 42% and is the second leading cause of AKI (after sepsis) in the intensive care unit (ICU). CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Early detection of CSA-AKI could improve patient outcomes and health care costs through targeted interventions. Thus, identification of relevant biomarkers may lead to early diagnosis. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. Nowadays, little is known about relationship between PKN1 and CSA-AKI. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.
Interventions
OTHERPKN1 level
different PKN1 level after on-pump cardiac surgery
Sponsors
Zhongnan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients (≥18 years old) underwent on-pump cardiac surgery * admitted to ICU immediately after surgery
Exclusion criteria
* Patients younger than 18 years * with prior AKI * end-stage kidney disease * need for chronic hemodialysis * pregnant patients * unable to give written consent for participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the development of CSA-AKI | 1 Week | the development of CSA-AKI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| AKI severity | 1 Week | AKI stage 1，stage 2，stage 3 |
| need for RRT | 1 Week | Reflect kidney function |
| duration of AKI (≥7 days) | 1 Week | Reflect kidney function |
| length of ICU stay | up to 28 days | Reflect patient prognosis |
| post-operative hospital stay | up to 28 days | Reflect patient prognosis |
Countries
China
Outcome results
None listed