The Role of Serotonin in Intensive Care Patients

The Role of Serotonin in Respiratory and Circulatory Failure in Intensive Care Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05386199

Acronym

SERO-22

Enrollment

250

Registered

2022-05-23

Start date

2022-05-25

Completion date

2024-12-31

Last updated

2022-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest With Successful Resuscitation, Multiple Trauma, Sepsis, Septic Shock

Keywords

Serotonin, 5-hydroxytryptamine, 5-HT, 5-hydroxyindoleacetic acid, 5-HIAA, Platelet poor plasma-serotonin, PPP-serotonin

Brief summary

Sepsis, cardiac arrest and multiple trauma are potentially life-threatening conditions and common reasons for intensive care unit (ICU) admission. The aim of this study is to investigate the role of the signaling substance serotonin in blood in these conditions.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

ICU-PATIENTS Inclusion criteria: * Active treatment of sepsis, septic shock, cardiac arrest with ROSC or severe multiple trauma. * Age over 18 years * Written consent from the patient or preliminary consent from the next of kin. * Receiving mechanical ventilator treatment upon inclusion. * Arterial and central venous cannulas present.

Exclusion criteria

* Withdrawal of consent * Serotonergic carcinoid syndrome, short bowel or other considerable comorbidity altering serotonin content in blood. * Intoxication prior to ICU admission. HEALTHY CONTROLS Inclusion criteria: * Age over 18 years and signed written consent. * Conformed to diet and activity restrictions.

Design outcomes

Primary

Measure	Time frame	Description
PPP-serotonin	As soon as possible after ICU admission. No more than 3 days after admission.	Serotonin in platelet poor plasma

Secondary

Measure	Time frame	Description
PPP-serotonin	End of first week at ICU, an average of 5 days after admission.	Serotonin in platelet poor plasma
Platelet serotonin	As soon as possible after ICU admission. No more than 3 days after admission.	Serotonin in platelets

Other

Measure	Time frame	Description
Plasma 5-HIAA	As soon as possible after ICU admission. No more than 3 days after admission.	5-hydroxyindoleacetic acid in plasma
Urine 5-HIAA	As soon as possible after ICU admission. No more than 3 days after admission.	5-hydroxyindoleacetic acid in urine

Countries

Norway

Contacts

Primary ContactMorten Rostrup, MD PhD

morteros@uio.no+4722119338

Backup ContactNikolai R Aarskog, MD

n.r.aarskog@medisin.uio.no+4722119338

Outcome results