Microbial Colonization, Preterm Birth
Conditions
Brief summary
This prospective cohort study was conducted in the Christiana Care Health System Neonatal Intensive Care Unit. It occurred at two time periods: Time period 1 included infants admitted to the traditional, open bay NICU. Time period 2 included infants admitted to the new private, single family room NICU. There was a 3 month period between Time period 1 and Time period 2 to ensure that there was no patient overlap. Stool samples and environmental samples were collected at 1 and 4 weeks after birth in both time periods. The objective of this study was to establish the gastrointestinal microbiome of infants born at less than 32 weeks gestation admitted to the exiting open bay NICU and compare it to the gastrointestinal microbiome of infants born at less than 32 weeks admitted to the new private, single family room NICU.
Interventions
OTHERObservational
This was an observational study which involved collection of stool samples and environmental samples at 1 week and 4 weeks of life.
Sponsors
University of Delaware
Christiana Care Health Services
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Weeks to 6 Months
Healthy volunteers
Yes
Inclusion criteria
* Less than 32 weeks gestation at birth
Exclusion criteria
* Infants in Time period 2 that were admitted to the traditional, open bay NICU
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microorganisms identified in stool samples | 4 weeks | Microorganisms identified in stool samples obtained at weeks 1 and 4 of life using the 16s rRNA sequencing based technique. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microorganisms identified in environmental samples | 4 weeks | Microorganisms identified in samples obtained from the counter, floor, and incubator top or inside wall at weeks 1 and 4 of life using the 16 s rRNA sequencing based technique. |
Countries
United States
Outcome results
None listed