Valuation in Depressed Mood, Anhedonia, and Anxiety

Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05384158

Enrollment

252

Registered

2022-05-20

Start date

2021-08-01

Completion date

2027-07-01

Last updated

2026-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurobehavioral Components of Reward and Loss Valuation

Keywords

depression, anxiety, anhedonia

Brief summary

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed description

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Interventions

BEHAVIORALcognitive behavioral therapy

cognitive behavioral therapy

BEHAVIORALvaluation with instruction

repeat laboratory sessions of computerized learning game

BEHAVIORALvaluation without instruction

repeat laboratory sessions of computerized learning game

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 50 Years

Healthy volunteers

Inclusion criteria

* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion criteria

* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Design outcomes

Primary

Measure	Time frame	Description
change in proportion correct on the 'N-arm bandit learning task'	study entrance to study exit, an average of 12 weeks	change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit

Secondary

Measure	Time frame	Description
change in depression symptoms (Beck Depression Inventory)	study entrance to exit, an average of 12 weeks	change in depression symptoms from study entrance to study exit
change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)	study entrance to exit, an average of 12 weeks	change in anxiety symptoms from study entrance to study exit
change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)	study entrance to exit, an average of 12 weeks	change in anhedonia symptoms from study entrance to study exit

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 29, 2026