Pediatric Cancer
Conditions
Keywords
pediatric cancers, exercise, insulin sensibility, metabolic syndrome
Brief summary
The main objective of this study is to evaluate the evolution of the sensitivity to insulin, a hormone that acts on sugar in the body, as well as other metabolic, motor and nutritional elements of children with cancer, according to the practice of intense physical activities or stretching. In view of the scientific work on this subject, it is expect to observe that the practice of intense physical activities will improve the results of the children in the metabolic, motor and nutritional evaluations, compared to the stretching program.
Detailed description
The protocol consists of 6 months of intense physical activity and stretching programs for children with solid cancer or haematological disease, starting at diagnosis. Evaluations will be performed at the first, third and sixth month of the programs and then six and eighteen months after they are stopped. The physical activity sessions will take place in the hospital during hospitalizations or by videoconference when the children are at home. The sessions are adapted to the needs, desires and abilities of the children and will take place two to three times a week. They will be mediated by various activities such as soccer, rugby, darts, muscle strengthening. Inclusion lasts two years.
Interventions
OTHERAdapted Physical Activity Strong
Children will practice physical activities combining aerobics and muscle strengthening. They will follow a 30-minute (for prepubescent children) or 60-minute (for pubescent children) Strong adapted physical activity session 2 to 3 times a week during hospitalization periods or by videoconference at home when they are not hospitalized.
Sponsors
University Hospital, Toulouse
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
Prospective randomized pilot study studying the parameters of two groups receiving physical activity management over a period of 6 months
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* age between 5 and 18 years old; * have a solid cancer or hematological disease; * be treated for the first time in pediatric oncology and hematology department; * have an estimated life expectancy at diagnosis of more than 6 months.
Exclusion criteria
* present a physical and/or psychological impossibility to follow an adapted physical activity program; * have a pre-existing heart disease that is not suitable for adapted physical activities; * have a known type 1 diabetes * have an obesity defined by a body mass index greater than or equal to the International Obesity Task Force 25 threshold
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin Sensitivity | 6 months | Homeostasis Model Assessment of Insulin Resistance |
Countries
France
Contacts
Primary ContactMarlène PASQUET, MD, PhD
Outcome results
None listed