Anemia, Critically Ill, Intensive Care Unit, Mechanical Ventilation, Morality, Organ Dysfunction Syndrome
Conditions
Keywords
Duration of mechanical ventilation, Duration of anemia, Intensive care unit, Mortality, Organ dysfunction
Brief summary
In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality. We aim to investigate the impact of duration of anemia and the duration of mechanical ventilation as well as clinical outcomes in critically ill patients in intensive care unit who required ventilatory support \>96 hr.
Detailed description
Anemia is one of the most common conditions encountered critically ill patients. Various mechanisms can put these patients at risk of anemia including gastrointestinal hemorrhage, iron deficiency, inflammation and infection, stress, and multiple blood testing. Anemia can affect cardiopulmonary function as depletion in oxygen content in body. In mechanically ventilated patients, anemia is associated with increased duration of mechanical ventilation, increased length of stay, and possibly increased mortality. Some research suggested that hemoglobin level \<8.5 g/dl was a potential risk factor for adverse outcome in critically ill patients required mechanical ventilation \>96 hr. However, most researches focused on hemoglobin levels and the associated adverse events in mechanically ventilated patients. To the best of our knowledge, there are few studies reported the impact of the duration of anemia and the clinical outcomes in these patients. We hypothesize that the short duration of anemia developed in mechanically ventilated patients has no effect on duration of mechanical ventilation. We, therefore, aim to investigate the impact of the duration of anemia on duration of mechanical ventilation in critically ill patients required ventilatory support \>96 hours.
Interventions
None listed
Sponsors
Mahidol University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients whose age of equal or more than 18 years old * Patients admitted to the surgical intensive care unit during the study period * Patients required ventilatory support with invasive mechanical ventilation for more than 96 hours
Exclusion criteria
* Patients whose data regarding time of beginning or ending of ventilatory support missed * Patients who are previously included in this study and are re-admitted
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of mechanical ventilation | 28 days after initiation of ventilatory support | Days patients received mechanical ventilation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Duration of anemia | 28 days after initiation of ventilatory support | Days patients had hemoglobin level \<8 g/dl while they were on ventilatory support |
| Cardiovascular dysfunction | 28 days after initiation of ventilatory support | SOFA cardiovascular component equal to 1, 3, or 4 |
| Respiratory dysfunction | 28 days after initiation of ventilatory support | SOFA respiratory component \>1 |
| Renal dysfunction | 28 days after initiation of ventilatory support | SOFA respiratory component \>1 |
| Gastrointestinal dysfunction | 28 days after initiation of ventilatory support | SOFA gastrointestinal component \>1 |
| Hematologic dysfunction | 28 days after initiation of ventilatory support | SOFA hematologic component \>1 |
| ICU length of stay | Up to 90 days following inclusion | Duration from ICU admission to ICU discharge |
| Hospital length of stay | Up to 90 days following inclusion | Duration from hospital admission to hospital discharge |
| ICU mortality | Up to 90 days following inclusion | Status at ICU discharge either alive or deceased |
| Hospital mortality | Up to 90 days following inclusion | Status at hospital discharge either alive or deceased |
Countries
Thailand
Contacts
PRINCIPAL_INVESTIGATORAnnop Piriyapatsom, MD
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed