Database for Intrauterine Adhesion, Intrauterine Adhesion, Risk Factors for Intrauterine Adhesion, Risk Stratification and Prognostic Assessment
Conditions
Brief summary
1\. To establish a follow-up database for uterine adhesions and a library of biological specimens for Intrauterine Adhesion. 2. using epidemiological surveys and biological analyses to screen risk factors for the development and prognosis of Intrauterine Adhesion. 3. Predictive models based on clinical and biochemical indicators, specimen testing and hysteroscopic images are also combined with statistical analysis and machine learning algorithms to enable patients' risk stratification and prognostic assessment.
Interventions
DIAGNOSTIC_TESTHysteroscopy
Hysteroscopy for CSGE, AFS, and endometrial receptivity assessment
DIAGNOSTIC_TESTUltrasonography
Ultrasonography for Uterus size and endometrial thickness
Sponsors
Hua Duan
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Previously diagnostic hysteroscopy confirmed adhesions combined with infertility or recurrent pregnancy loss (early pregnancy loss \>2) * Desiring to conceive * Ages between 20-45 years; * Patients without gynecological endocrine disorders (e.g. PCOS) and AMH\>1ng/ml; * Signing informed consent.
Exclusion criteria
* Hysteroscopy contraindications; * Hormone therapy contraindications; * Pregnancy contraindications; * History of malignant pelvic tumor and radiotherapy; * Severe hepatic or renal dysfunction; * Complicated with hematological disorders (eg.platelet dysfunction, severe anemia, blood-borne infections); * Male factor infertility(eg.seminal abnormalities).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of pregnancy | 2 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence rate of IUA | 3 month | Recurrence rate of Intrauterine Adhesion |
| Menstrual blood volume | 3 month | — |
| CSGE | 3 month | CSGE (Chinese Society of Gynaecological Endoscopy score), scale 0-28, higher scores mean a worse outcome |
| AFS | 3 month | AFS(American Fertility Association score), scale 1-12, higher scores mean a worse outcome |
Countries
China
Contacts
Primary ContactWang Sha, Dr.
Outcome results
None listed