Fistula-associated Anal Adenocarcinoma

Fistula-associated Anal Adenocarcinoma - a Twenty Years' Single-center Experience.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05381324

Enrollment

1004

Registered

2022-05-19

Start date

1999-01-01

Completion date

2022-05-01

Last updated

2022-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rectal Cancer

Brief summary

The fistula-associated anal adenocarcinoma is rare in patients suffering from anal fistulas. There is only little data available for this patient collective making characterization and management of this disease difficult. Late diagnosis and advanced tumor stage at diagnosis result in poor clinical outcome. It is the purpose of this study to evaluate patients clinically diagnosed with a FAAC and to further perform a histopathological characterization of the available tumor specimen.

Detailed description

All patients receiving surgery for an anal fistula in the years 1999 to 2019 at a tertiary university referral hospital were included in the analysis. A retrospective review of patients' charts was performed. Patients suffering from FAAC were eligible for histopathological analysis including immunohistochemistry and molecular profiling.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* anal fistula

Exclusion criteria

* previous cancer of the anal canal

Design outcomes

Primary

Measure	Time frame	Description
fistula-associated anal adenocarcinoma (FAAC)	1999-2019	include and analyze all patients suffering from FAAC

Outcome results