Faster Peritoneal Solute Transfer Rate and Survival in a Pre-APD and Icodextrin Peritoneal Dialysis Cohort

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05381051

Enrollment

430

Registered

2022-05-19

Start date

2015-01-01

Completion date

2020-12-31

Last updated

2022-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritoneal Dialysis

Brief summary

A fast peritoneal solute transfer rate (PSTR) has been linked to worse survival especially in continuous ambulatory peritoneal dialysis (PD) cohort. In more recent cohorts, where automated PD and icodextrin were more widely used, this association disappears. The current study intended to clarify whether fast PSTR is related to worse outcome in this single center cohort with minimal use of APD and no icodextrin and otherwise modern management practice. Our study found that baseline PSTR predicted patient outcome in univariate survival analysis but not in multivariate analysis. The relationship between comorbidity and faster baseline PSTR may partly explain it.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. Patients are Han Chinese; 2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization; 3. Patients successfully complete the first peritoneal equilibration test(PET); 4. Follow up regularly in our PD center.

Exclusion criteria

1. Patients from hemodialysis to peritoneal dialysis; 2. Patients who need peritoneal dialysis due to transplant-renal loss;

Design outcomes

Primary

Measure	Time frame	Description
The relationship between fast PSTR and worse outcome in PD.	The data collection time period of the study is over 10 years.	Baseline PSTR predicted patient outcome in univariate survival analysis but not in multivariate analysis. The relationship between comorbidity and faster baseline PSTR may partly explain it.

Outcome results