Chronic Kidney Diseases
Conditions
Keywords
epidemiological survey, renal failure, decreased renal function, dialysis, low protein diet, treatment alternatives, Clinical Frailty Scale, Mini Nutritional Assessment (MNA), Bansal Score
Brief summary
The decision making in the Czech nephrology offices depends on the local common practice which is likely to be heterogenous. In other words, the same patient would be indicated to different therapy and regimen at different sites. To date, the practices and treatment paths have not been described. The aim of the present epidemiological research is to characterize the population of CKD patients at the point of treatment choice and to outline the motivation of nephrologist to initiate particular therapy.
Detailed description
This is epidemiological (observational) cross-sectional survey. Data for the research will be obtained from clinical records and patient´s questionnaires and transcribed into electronic case report forms (eCRF) by physician anonymized using subject ID. This observational research will not impose any additional procedures, assessments, or changes in addition to the routine management of subjects. The research does not aim to follow treatment with a single medicinal product. The management of patients will be described in general terms. Names of active substances will be collected rather than the names of individual products.
Interventions
None listed
Sponsors
Value Outcomes Ltd.
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Adult patient of 18 years and older * Signed consent with processing of personal data as per the GDPR and the applicable national legal requirements * Chronic kidney disease (CKD) category 4 to 5 characterized by GFR \< 30 ml/min/1.73m2 for at least 3 months
Exclusion criteria
* Patients on chronic dialysis * Patient waiting for kidney transplant * Patient requiring indication of dialysis (e.g., life-threatening changes in fluid, electrolyte, and acid-base balance, serositis, pruritus, inability to control blood pressure, lethargy or other changes in mental status, symptoms of uraemia, GFR \< 10 ml/min/1.73 m2) * Patient with altered mental state unable to fill patient questionnaires
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sociodemographic parameters | through study completion, an average of 3 months | age, gender, ethnicity, health insurance company, education, marital status and cohabitation, employment status/disability, type of employment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Laboratory parameters | through study completion, an average of 3 months | albumin (in g/l) |
| Prognosis | through study completion, an average of 3 months | Bansal score (min. 0, max. 17, higher score means the worse prognosis) |
| Functional status/frailty/performance | through study completion, an average of 3 months | Clinical frailty scale (min. 1, max. 9, higher score means higher frailty) |
| Medical history and anthropometry | through study completion, an average of 3 months | BMI (in kg/m\^2) |
| Decision of future management | through study completion, an average of 3 months | Choice of future management (conservative management, conservative management with ketoanalogues, dialysis) |
| Physician attitude to the choice of therapy + reasons | through study completion, an average of 3 months | Physician motivation/reasons for treatment choices |
| Patient attitude to the choice of therapy + reasons | through study completion, an average of 3 months | Patient motivation/reasons for treatment choices |
| Nutrition | through study completion, an average of 3 months | nutritional status (Full MNA assessment), ketoanalogues, salt intake, protein intake, nutritional education (flyers, consultations etc.), attitude/future adherence to prescribed dietary restrictions |
Countries
Czechia
Contacts
Primary ContactJan Tužil, Mgr.
Outcome results
None listed