Esophageal Motility Disorders
Conditions
Keywords
contraction reserve
Brief summary
rapid swallow (MRS) can assess the contractile reserve capacity of the oesophageal body and identify and diagnose oesophageal motility disorders, but the impact of preoperative oesophageal reserve capacity on postoperative symptoms and motility in patients with GERD remains unclear. The aim of this study was to assess the effect of pre-operative oesophageal reserve capacity on post-reflux symptoms and motility in patients with GERD by using a high-resolution oesophageal manometry-based provocation test, MRS, to track pre-operative ineffective oesophageal motility (IEM).
Detailed description
Lower oesophageal sphincter relaxation is an important cause of GERD and ineffective oesophageal motility may be associated with GERD, but the mechanism of oesophageal corporal motility disorders is unclear. High-resolution manometry (HRM) has shown to be more accurate than conventional manometry in assessing oesophageal motility, and can provide guidance for GERD surgery. The aim was to conduct a cohort study to investigate the yu'h of patients with preoperative esophageal motility disorders with or without esophageal reserve, based on the assessment of esophageal motility by high-resolution esophageal manometry to follow up changes in esophageal motility and symptoms in patients after anti-reflux surgery.
Interventions
OTHERFollow-up visits
Regular follow-up visits to record information about the patient's surgery and routine post-operative examinations
Sponsors
Shandong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 years old * Patients to be treated surgically for gastroesophageal reflux disease * Ineffective esophageal motility diagnosed by high resolution esophageal manometry according to Chicago Classification version 4.0 * Obtaining Informed Consent
Exclusion criteria
* Previous other upper gastrointestinal surgery * Pregnant women and other people with contraindications to surgery and tests * Other specifically defined esophageal motility disorders, such as nutcracker esophagus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of changes in oesophageal motility after anti-reflux surgery compared to pre-surgery | 2 year follow-up after anti-reflux surgery | Using high resolution manometry to assess changes in oesophageal motility after anti-reflux surgery, compared to pre-surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of changes of post-anti-reflux surgery symptoms | 2 year follow-up after anti-reflux surgery | Reflux Symptom Questionnaire Assessment to assess the changes of symptoms |
Countries
China
Contacts
Primary ContactFeiXue Chen, MD
Backup ContactYanqing Li, phD
Outcome results
None listed