Stimulant Use, MDMA ('Ecstasy'), Social Behavior, Motivation
Conditions
Brief summary
To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers
Interventions
DRUGplacebo oral tablet
Participants will be given a placebo capsule that will only contain lactose.
DRUGMDMA
Participants will be given 125 mg of MDMA.
DRUGMethamphetamine
Participants will be given 20 mg of MA.
Sponsors
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI between 19 and 30 (no one under 130 lbs) * Smokers smoking less than 25 cigarettes per week * Have used ecstasy no more than 40 times with no adverse responses.
Exclusion criteria
* High blood pressure * Any medical condition requiring regular medication * Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis * Individuals with a history of dependence on stimulant drugs. * Women who are pregnant or trying to become pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Profile of Mood States | Time Frame: Baseline-72 hours after completion of the sessions | The POMS measures individuals' mood states. This is a validated scale to measure positive and negative mood states. The POMS contains 30 items and assesses six identified mood factors: Tension-Anxiety, Depression-Ejection, Anger- Hostility, Vigor-Activity, Fatigue-Inertia, and Confusion-Bewilderment. Scoring of the instrument provides a global score of 0 to 120 or individual domain scores. Lower scores indicate better mood state. The POMS brief form is a simple self-rating instrument. |
Countries
United States
Outcome results
None listed