Does Topical Lidocaine Decrease Sweat During Exercise in the Heat?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05379283

Enrollment

Registered

2022-05-18

Start date

2022-05-15

Completion date

2022-09-15

Last updated

2024-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sweat Pore Closure

Keywords

thermoregulation, sweating, exercise

Brief summary

Subjects will walk on a treadmill at 3 mph and sweat will be collected from both forearms. One arm will be pretreated with topical lidocaine, and the other will act as the control.

Detailed description

Subjects will walk on a treadmill at 3 mph and sweat will be collected from both forearms. One arm will be pretreated with topical lidocaine, and the other will act as the control. Sweat will be collected via macroducts attached to each arm. Sweat production on each arm will be compared using t-tests.

Interventions

DRUGLidocaine

effect of lidocaine on sweat production during exercise in the heat

OTHERcontrol

one arm will be pretreated with topical lidocaine, the other arm will not

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

18-35 years of age -

Exclusion criteria

pregnant females \-

Design outcomes

Primary

Measure	Time frame	Description
volume of sweat produced during exercise following topical lidocaine	one hour of exercise	Volume of sweat produced during exercise following tipocal lidocaine

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026