Atherosclerotic Cardiovascular Disease
Conditions
Keywords
Atherosclerotic Cardiovascular Disease, Lipoprotein(a)
Brief summary
The purpose of this study is to characterize the distribution of lipoprotein(a) (Lp(a)) levels among participants with a history of ASCVD as defined by their medical history and is 2-fold: * Evaluate the distribution of Lp(a) value in the overall participants with documented history of ASCVD * Evaluate the distribution of Lp(a) value in participants with documented history of ASCVD by demographics and regions
Interventions
OTHERLp(a) Screening
Participants will provide demographic information and have a blood draw for Lp(a) levels if they are unknown.
Sponsors
Amgen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Signed informed consent * History of ASCVD
Exclusion criteria
* Participants known to be currently receiving investigational drug in a clinical study * Participants with a diagnosis of end-stage renal disease or requiring dialysis * Participants who have received lipoprotein apheresis to reduce Lp(a) within 3 months prior to enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of participants with elevated Lp(a) with documented history of ASCVD | Up to approximately 2 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lp(a) Levels | Up to approximately 2 weeks | Blood sampling will be performed in cases where Lp(a) values are not available at enrollment. In cases where Lp(a) values are available, data will be collected retrospectively. |
| Lp(a) Levels stratified by demographics and region | Up to approximately 2 weeks | — |
Countries
Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hong Kong, Hungary, Iceland, Italy, Japan, Lithuania, Mexico, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, South Korea, Spain, Sweden, Switzerland, Taiwan, Turkey (Türkiye), United Kingdom, United States
Outcome results
None listed