Antiphospholipid Syndrome in Pregnancy
Conditions
Brief summary
This investigation is on placental pathological changes and inflammatory factors associated with obstetric antiphospholipid syndrome.
Detailed description
1\. To clarify the correlation between antiphospholipid antibody, ACC1 expression level, Treg cell and placental pathological changes associated with antiphospholipid syndrome. 2. Reveal that antiphospholipid antibodies affect Treg cell differentiation through the key enzyme of lipid metabolism ACC1.
Interventions
OTHERno intervention
no intervention
Sponsors
Peking University People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. pregnant women with antiphospholipid syndrome (diagnosed by experts with clinical evidence) and healthy pregnant women without antiphospholipid syndrome as a control group 2. consent to join this study and finish the informed consents
Exclusion criteria
pregnant women with other autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| expression of ACC1 in placenta in pregnancy with/without antiphospholipid syndrome | in two years |
Countries
China
Contacts
Primary ContactJingjing Yang, deputy chief physician, doctor
Backup ContactXinyang Ma, resident, bachelor
Outcome results
None listed