Dyspepsia
Conditions
Brief summary
Functional dyspepsia (FD) is a common gastrointestinal disease with high morbidity. Due to the drop in estrogen level, perimenopausal women with FD (PMFD) have an increase in emotional disorders such as depression, anxiety and sleep disorder.
Detailed description
the research will include 30 FD women during their perimenopause to receive for 8 weeks the following: relaxation therapy (Benson relaxation), physical exercise (on treadmill), and proton pump inhibitors. Also, the research will include another 30 FD women during their perimenopause to receive for 8 weeks the following: relaxation therapy (Benson relaxation) and proton pump inhibitors
Interventions
BEHAVIORALrelaxation and physical activity
This FD women group will include 30 females who will be treated for 8 weeks with oral proton pump inhibitors (taken one time daily with 40 mg pantoprazole-tablet dose), Benson relaxation daily sessions (twenty minutes at morning time and another 20 minutes at the evening time), physical activity ( five session per the week conducted on treadmill, 30 minutes in the first treatment month and 40 minutes in the second treatment month)
BEHAVIORALrelaxation
This FD women group will include 30 females who will be treated for 8 weeks with oral proton pump inhibitors (taken one time daily with 40 mg pantoprazole-tablet dose) and Benson relaxation daily sessions (twenty minutes at morning time and another 20 minutes at the evening time)
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* perimenopausal women With FD symptoms
Exclusion criteria
* other gastrointestinal disease * Cardiovascular, metabolic, respiratory, renal complaints * Pregnancy * Women in Lactation * neurological / Psychic Women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cortisol | It will be measured after 8 weeks | stress hormone will be measured in serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glasgow dyspepsia severity score | It will be measured after 8 weeks | it is questionnaire assessing severity of dyspepsia |
| Visual analogue scale | It will be measured after 8 weeks | it is a scale for assessment of severity of abdominal syymptoms |
| depression anxiety stress scales-42 | It will be measured after 8 weeks | it is a 42 item self-report scale designed to measure the negative emotional states of depression, anxiety and stress |
| Pittsburgh sleep quality index | It will be measured after 8 weeks | it is a questionnaire for sleep quality assessment |
| Estradiol | It will be measured after 8 weeks | one of endogenous estrogen in the serum of women |
Countries
Egypt
Contacts
Primary ContactAli Ismail, lecturer
Outcome results
None listed