Thyroid Nodule Gene Sequencing in a Danish Population

Thyroid Nodule Gene Sequencing in a Danish Population - a Pilot Study

Status

Active, not recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05377736

Enrollment

Registered

2022-05-17

Start date

2022-03-01

Completion date

2027-01-18

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Cancer, Thyroid Nodule (Diagnosis)

Brief summary

This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population. Patients with thyroid nodules suspected of malignancy is included prospectively. Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.

Interventions

GENETICMolecular analyses

Collect thyroid tissue for molecular analysis from the histological specimen collected by routine surgery

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Thyroid nodule \>1.5 cm * BSRTC: IV, V, og VI

Exclusion criteria

* No surgical specimen available * Purely cystic nodules

Design outcomes

Primary

Measure	Time frame	Description
DNA alterations	Two years	Whole genome sequencing by next generation sequencing
RNA alterations	Two years	Total RNA sequencing including circular RNA, micro RNA and messenger RNA
DNA methylation	Two years	Whole Genome Bisulfite Sequencing
Circulating tumor DNA	Two years	Whole genome sequencing of leucocyt DNA and circularing DNA

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026