Adverse Childhood Experiences, Breastfeeding, Sickle Cell Disease
Conditions
Keywords
Sickle cell disease, Adverse Childhood Experiences, Breastfeeding
Brief summary
This study is being conducted to determine the relationship between early childhood exposures, such as Adverse Childhood Experiences, Social Determinants of Health and nutrition/breastfeeding, among children with sickle cell disease, and behavioral interventions aimed to reshape psychological resilience and lifestyle factors towards positive health outcomes.
Detailed description
During year 3 of the award period, 20 mother-infant dyads will be randomly assigned to either a community-based breastfeeding support group or observation. Acceptability to enrollment, intervention adherence for at least 6 months and preliminary effectiveness will be captured. Biomarkers of inflammation, development of asthma and incidences of pain and/or acute chest syndrome will be compared among the intervention and control groups.
Interventions
BEHAVIORALBreastfeeding support group
community-based breastfeeding support group aimed to increase exclusive breastfeeding success rates among Black women
OTHERObservation
Observe prospectively for breastfeeding initiation, duration and longitudinal health of child with sickle cell disease
Sponsors
University of Alabama at Birmingham
National Heart, Lung, and Blood Institute (NHLBI)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Randomized control trial
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* mother of infant with sickle cell disease * resides within the city of Birmingham, Alabama or in close proximity
Exclusion criteria
* prescribed teratogenic medications * no/limited internet access
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acceptance and Retention of Mothers of Infants with Sickle Cell Disease to a Community-based Breastfeeding Intervention | 6 months | acceptance (number of mothers enrolled/number of mothers approached) and retention (number of mothers to complete 6 month support group intervention/number enrolled) |
| Preliminary Effectiveness | 2 years | Percentage of mothers of infants with sickle cell disease that successful complete 6 months of breastfeeding, comparing the intervention vs. control groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Asthma | 4 year follow up period | Prevalence of asthma among children with sickle cell disease that were breastfed compared to those that were not |
| Acute chest syndrome | 4 year follow up period | Incidence rate of episodes of acute chest syndrome among children with sickle cell disease that were vs. were not breastfed |
Countries
United States
Contacts
CONTACTBrandi M Pernell, DNP, MSPH
PRINCIPAL_INVESTIGATORBrandi M Pernell, DNP, MSPH
University of Alabama at Birmingham
Outcome results
None listed