Prediction Model of Vitamin D Deficiency

Prediction Model of Vitamin D Deficiency in Critically Ill Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05376774

Enrollment

662

Registered

2022-05-17

Start date

2022-05-01

Completion date

2022-09-01

Last updated

2022-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness

Keywords

critical care, vitamin D

Brief summary

Many studies have pointed out that patients with vitamin D deficiency have a longer stay in the intensive care unit and a poor prognosis. Previous multi- center prospective observational study in Taiwan reveals that the prevalence of vitamin D deficiency in critically ill patients in northern Taiwan is 59%, and the prevalence of severe vitamin D deficiency is 18%. Several prediction models of vitamin D deficiency had been built for the general population but not patients admitted in intensive care units. This multi-center retrospective study aims to develop and validate a score-based prediction model for severe vitamin D deficiency in critically ill patients. Investigators will review the data of previous multicenter, prospective, observational study. For temporal validation, the data will be divided into a derivation cohort (first 80% of the data set based on chronology) and a validation cohort (the remaining data set). The development and validation of the models will be carried out following the recommendations established in the Transparency Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) initiative.

Interventions

OTHERAdmitted to intensive care units

Admitted to intensive care units

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients admitted to intensive care units

Exclusion criteria

* aged \< 20 years * admitted to intensive care unit longer than 28 days * body max index \< 18 kg/m2 * receive vitamin D supplement \> 3000 IU/day * previously admitted to intensive care unit within 3 months * have parathyroid disease, rickets, or severe liver cirrhosis \[Child C\]

Design outcomes

Primary

Measure	Time frame	Description
Performance of the score-based prediction model	1 day	Area under the receiver operating characteristic (AUROC) and area under precision recall curve (AUPRC) of the prediction models for severe vitamin D deficiency

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026