Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction
Conditions
Keywords
Ablation, HFpEF, atrial fibrillation, exercise capacity, peak oxygen consumption
Brief summary
In a prospective, observational pilot study of patients scheduled for an atrial fibrillation (AF) ablation at the University of Vermont Medical Center the investigators will compare exercise capacity before and four months after AF ablation.
Detailed description
Patients ≥ 18 years of age who are scheduled for an AF ablation at the University of Vermont Medical Center will be screened for the following inclusion criteria: H2FpEF score of ≥ 6 (corresponding to ≥90% probability of HFpEF (19)) AND echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50% AND at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea). Exclusion criteria: (1) Life expectancy \<12 months, (2) moderate or more valvular disease, (3) inability to walk on a treadmill. Patients with early recurrent AF (defined as AF after a 12-week post-procedural blanking period accounting for post-ablation inflammation) will be withdrawn from the study and not proceed to the 4 month follow up visit.
Interventions
None listed
Sponsors
University of Vermont
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 110 Years
Healthy volunteers
No
Inclusion criteria
* H2FpEF score of ≥ 6 (corresponding to \>90% probability of HFpEF (19)) * echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50% * at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea). * AF ablation scheduled at UVMMC
Exclusion criteria
* Life expectancy \<12 months * moderate or more valvular disease * inability to walk on a treadmill
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in peak VO2 | before AF ablation and 4 months after AF ablation | cardiopulmonary exercise testing will be performed & peak VO2 measured at baseline & follow up visit |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in KCCQ score | before and 4 months after AF ablation | Kansas City Cardiomyopathy Questionnaire (KCCQ) will be obtained at baseline visit & again at ablation follow up visit. Scale 0-100 with higher scores signifying better quality of life. |
| Percent change in NTproBNP | before and 4 months after AF ablation | Initial sample taken day of AF ablation as is standard of care; reassessed at 4 month f/u visit |
Other
| Measure | Time frame | Description |
|---|---|---|
| Difference in peak VO2 in patient with vs. without chronic rate control | 4 months post-ablation | 4 months f/u cardiopulmonary exercise testing performance compared between those with and without chronic rate control |
Countries
United States
Contacts
Primary ContactNicole Habel, MD
Backup ContactAmy Henderson
Outcome results
None listed