Skin Condition
Conditions
Brief summary
To assess cherry collagen drink on skin condition improvement
Interventions
DIETARY_SUPPLEMENTCherry collagen drink
consume 1 sachet per day
DIETARY_SUPPLEMENTPlacebo drink
consume 1 sachet per day
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged above 20 years old
Exclusion criteria
* Subject who is not willing to participate in this study. * Patients with diseases of the skin, liver, kidney. * Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Received facial laser therapy, chemical peeling or UV overexposure (\> 3 hr/week) in the past 4 weeks. * Constant drug use * Students who are currently taking courses taught by the principal investigator of this trial. * Body weight \< 50 kg.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin texture | Change from Baseline skin texture at 8 weeks | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units |
| The change of skin collagen density | Change from Baseline skin collagen density at 8 weeks | DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units |
| The change of skin elasticity | Change from Baseline skin elasticity at 8 weeks | Soft Plus was utilized to measure skin elasticity. Units: arbitrary units |
| The change of skin wrinkles | Change from Baseline skin wrinkles at 8 weeks | VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin spots | Change from Baseline skin spots at 8 weeks | VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units |
| The change of skin UV spots | Change from Baseline skin UV spots at 8 weeks | VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units |
| The change of skin brown spots | Change from Baseline skin brown spots at 8 weeks | VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units |
| The change of SOD-RBC of blood | Change from Baseline SOD-RBC at 8 weeks | Venous blood was sampled to measure SOD-RBC |
| The change of GST-RBC of blood | Change from Baseline GST-RBC at 8 weeks | Venous blood was sampled to measure GST-RBC |
| The change of blood total antioxidant capacity (TAC) | Change from Baseline TAC at 8 weeks | Venous blood was sampled to measure concentrations of TAC |
| The change of desmosine of blood | Change from Baseline desmosine at 8 weeks | Venous blood was sampled to measure concentrations of desmosine |
| The change of TNF-alpha of blood | Change from Baseline TNF-alpha at 8 weeks | Venous blood was sampled to measure concentrations of TNF-alpha |
| The change of transepidermal water loss (TEWL) | Change from Baseline TEWL at 8 weeks | Tewameter® TM300 was utilized to measure TEWL. Units: g/hm² |
| The change of t-GSH of blood | Change from Baseline t-GSH at 8 weeks | Venous blood was sampled to measure t-GSH |
| The change of skin melanin index | Change from Baseline skin melanin index at 8 weeks | Soft Plus was utilized to measure skin melanin index. Units: arbitrary units |
| The change of skin L* value | Change from Baseline L* value at 8 weeks | Chroma Meter MM500 was utilized to measure skin L\* value. Units: arbitrary units, 0-100 |
| The change of skin moisture | Change from Baseline skin moisture at 8 weeks | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 |
Other
| Measure | Time frame | Description |
|---|---|---|
| The change of liver function biomarkers (AST, ALT) of blood | Change from Baseline liver function biomarkers at 8 weeks | Venous blood was sampled to measure liver function biomarkers |
| The change of self-assessment skin condition | Change from Baseline skin condition at 8 weeks | A self-assessment questionnaire was collected to evaluate skin condition |
| The change of renal function biomarkers (creatinine, BUN) of blood | Change from Baseline renal function biomarkers at 8 weeks | Venous blood was sampled to measure renal function biomarkers |
Countries
Taiwan
Outcome results
None listed