Sickle Cell Disease, Vaso-occlusive Crisis
Conditions
Keywords
sickle cell disease, vaso-occlusive crisis, reticulocyte count, thrombin generation assay, hypercoagulability
Brief summary
Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation. The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.
Interventions
BIOLOGICALErythrocytic parameters and thrombin generation assay measurement
Erythrocytic parameters and thrombin generation assay measurement
Sponsors
BILLOIR
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Sickle cell disease
Exclusion criteria
* \<18 years * pregnancy * Patient under protective guardianship or curatorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hospitalisation for Vaso-occlusive crisis within one years | 1 year | Following injury consultation, evaluation of biological markers predicting vaso-occlusive crisis requiring hospitalisation in the year |
Countries
France
Outcome results
None listed