Outcome of Root Canal Treatments Obturated With Calcium Silicate Based Sealers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05376033

Enrollment

109

Registered

2022-05-17

Start date

2019-02-01

Completion date

2022-02-01

Last updated

2022-05-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endodontically Treated Teeth

Keywords

root canal treatment, healing rate, warm obturation technique, bioceramic sealer

Brief summary

The clinical use of a flowable premixed calcium-silicate bioceramic sealer used in association with warm carrier-based/single-cone technique will be compared with epoxy resin-based sealer with carrier-based technique.

Detailed description

Healthy consecutive patients (n= 109) requiring 141 root canal treatments were enrolled in this study and divided in 3 groups (Group 1: Ceraseal + single cone cold technique n=47. Group 2: Ceraseal + Carrier-based technique n=47. Group 3 AH Plus + Carrier based technique n=47). Periapical X-rays were taken preoperatively, after root canal filling and after 6, 12 and 24 months. Two evaluators blindly assessed the Periapical Index (PAI) and sealer extrusion in the 3 groups (k =0.90). Healing rate and survival rate were also analysed. Chi square tests was used to analyse significant differences among the groups. Multilevel analysis was performed to analyse the factors associated to healing status and survival status.

Interventions

OTHERroot canal filling with Ceraseal sealer

root canal filling with Ceraseal sealer

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

1. age 18-75 years 2. no use of antiresorptive or antiangiogenic drug 3. healthy status (ASA 1 or 2). 4. Needing one or more root canal treatment

Exclusion criteria

1. Teeth with less than 2 walls of structural integrity 2. Wide apexes (\>40 diameter) 3. ASA \> 3, 4. Any pathology that could compromise bone healing or the immune response, 5. pregnancy or breast feeding 6. heavy smoking (\>15 cigarettes/day), (Tverdal & Bjartveit 2006) 7. exposure to radiation therapy focussed on the head and neck region and malignant disease directly involving the jaws. 8. Lacks of occlusal contacts

Design outcomes

Primary

Measure	Time frame	Description
Healing rate	24 months	Periapical index minor than 3 at the endline

Secondary

Measure	Time frame	Description
Survival rate	24 months	presence of root canal treated tooth at the endline

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026