Clinical and Genetic Markers of Bone Metabolism in Children Under One Year

Clinical and Genetic Markers of Bone Metabolism in Children Under One Year of Age in the Kazakh Population

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05375331

Enrollment

245

Registered

2022-05-16

Start date

2020-12-31

Completion date

2024-03-01

Last updated

2023-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Remodeling Disorder, Child Development, Genetic Change

Brief summary

The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis of the relationship of molecular genetic markers with indicators of bone metabolism.

Detailed description

Children under the age of one year of Kazakh nationality born in Aktobe will be examined. Each child included in the study will have an individual registration card, where information about the health status of the child and the health status of the mother during pregnancy will be filled in. A biochemical analysis will be determined for the level of calcium, phosphorus, calcitonin, parathyroid hormone, osteocalcin, vitamin D in blood serum and deoxypyridinoline in urine. Blood will be taken to determine the genetic polymorphism of VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759). The state of bone tissue remodeling (osteocalcin, vitamin D, Ca, P, calcitonin, deoxypyridinoline) will be revealed The frequencies of allelic variants of the VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) genes in children under the age of one year in the population of Kazakhstan were determined.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 1 Years

Inclusion criteria

-Children 0 -12 months old

Exclusion criteria

* Musculoskeletal system diseases; * Severe chronic somatic diseases; * Supplementation of vitamin D in a therapeutic dose; * Lack of consent of the parents or legal representatives to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Optimization of the method for diagnosing bone metabolism disorders in children under one year old in the Kazakh population	2 years	The state of bone metabolism was assessed using the quantitative content of calcium, phosphorus, vitamin D, osteocalcin, and parathyroid hormone.

Countries

Kazakhstan

Contacts

Primary ContactIrina Kim

irina.kim.90@mail.ru+7015281354

Backup ContactMairamkul Zharlykasinova

kimsab@mail.ru+77086454298

Outcome results