Ectopic Pregnancy, Hysterectomy, Primary Ciliary Dyskinesia, Salpingectomy
Conditions
Keywords
miscarriage, tubal cilia
Brief summary
Primary Ciliary Dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women
Detailed description
Primary Ciliary Dyskinesia (DCP) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. However, there is very little data in the literature on the structure and function of tubal cilia in women with DCP. Before considering a study of tubal cilia in patients with DCP, it seems necessary to specify in DCP patients or not DCP, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of GEU
Interventions
PROCEDUREsalpingectomy
Removal of one of the fallopian tubes.
PROCEDUREhysterectomy
remove the uterus, whole or only part. It may also involve the removal of the cervix, ovaries, fallopian tubes and other surrounding structures.
Sponsors
Centre Hospitalier Intercommunal Creteil
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with scheduled salpingectomy (Ectopic pregnancy, hysterectomy for prolapsus, adenomyosis or myomectomy) * Major patients ( \>18 years)
Exclusion criteria
* Patient not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| morphological of tubal cilia | through study completion, an average of 6 week after surgery | Molecular compositor of tubal ciliar by immunofluorescence study of 14 proteins in vivo and in vitro (tissue cells from patient fallopian tubes) |
| Molecular difference in tubal cilia between patients with or without GEU salpingectomy | through study completion, an average of 6 week after surgery | compares molecular compositor of tubal ciliar by immunofluorecence study of 14 proteins in vivo and in vitro between patients with or without GEU salpingectomy |
| molecular tubal cilia | through study completion, an average of 6 week after surgery | Ultrastructure morphology of tubal cell cilia by electron microscopy |
| functional composition of tubal cell by video microscopy | through study completion, an average of 6 week after surgery | amplitude of moment by video microscopy |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORRana i MITRI-FRANGIEH
Centre Hospitalier Intercommunal Créteil
Outcome results
None listed