Interstitial Lung Disease, Pulmonary Rehabilitation
Conditions
Keywords
interstitial lung disease, nasal high flow oxygen therapy, endurance test, pulmonary rehabilitation
Brief summary
in this study, the investigators aim to describe the effects of highflow nasal canulae oxygen therapy (HFNC) on respiratory muscle function during exercise in patients with fibrosing interstitial lung diseases (ILD) during an endurance test
Interventions
DEVICEhigh flow nasal canulae
high flow nasal canulae is a oxygen therapy technic which allows the administration of warmed and humidified oxygen with a flow up to 50L/Min and a monitored FiO2. Physiological previous studies reported various effects of this technic especially on work of breathing. In our study the investigators aim to test this physiological property during exercise.
DEVICEVentury mask
Ventury mask is a oxygen therapy technic which allows the administration with a mask of oxygen with a flow up to 15L/Min and a monitored FiO2.
Sponsors
ADIR Association
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
All patients were randomly allocated into two groups using the block randomization technique (blocks of eight patients) in a 1:1 ratio. In group A, a high-intensity constant work-rate endurance test using Venturi mask (VM) was performed on first, and a test using high-flow nasal canulae oxygen therapy (HFNC) was performed next. In group B, a high-intensity CWRET using HFNC was performed first, and a test using VM was performed next.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cared for as part of a respiratory rehabilitation program (ADIR association) * Presenting diffuse fibrosing interstitial pneumonitis, documented by CT scan data and whatever its etiology * Presenting severe hypoxemia in ambient air (SpO2\<90%) during an exercise test (6-minute walk test or functional exercise test)
Exclusion criteria
* Patient with a contraindication to carrying out a respiratory rehabilitation program * Patient having presented an exacerbation of PID, pneumothorax or pneumomediastinum in the 3 months preceding potential inclusion * Tracheostomized patient * Patient with a contraindication to the placement of a nasogastric tube * Pregnant or breastfeeding women or women of childbearing age without effective means of contraception (a pregnancy test will be carried out) * Protected adult patient (guardianship or curatorship) * Patient deprived of liberty by court or administrative decision * Refusal of patient participation or consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ptdi swing | during the intervention, at isotime | To compare the change in transdiaphragmatic pressure between baseline and peak during inspiration (Ptdi swing) between HFNC and VM in patients with fibrosing Interstitial Lung Disease in stable state, at isotime. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PTPoeso | during the intervention, at isotime | on effort at isotime, comparison between HFNC and VM of the respiratory Pressure Time Product during a respiratory cycle (PTPoeso) |
| Poeso swing | during the intervention, at isotime | on effort at isotime, comparison between HFNC and VM of variation of oesophagal pressure between the base state and the peak (Poeso swing) |
| DeltaPtdi/DeltaEAdi | during the intervention, at isotime | on effort at isotime, comparison between HFNC and VM of the electromechanical coupling of the diaphragm (ratio of variation of the transdiaphragmatic pressure by the variation of electrical activity of the diaphragm (EAdi) between the start of inspiration and the end of expiration, (DeltaPtdi/DeltaEAdi) |
| PTPdi | during the intervention, at isotime | on effort at isotime, comparison between HFNC and VM of diaphragmatic pressure time product during a respiratory cycle (PTPdi) |
| TcCO2 | during the intervention, at isotime | on effort at isotime, comparison between HFNC and VM of transcutaneous CO2 measurement (TcCO2) |
| Tlim | during the intervention, at the end of endurance test | Comparison of endurance time (Tlim) between HFNC and VM |
| SmO2 | during the intervention, at isotime | on effort at isotime, comparison between HFNC and VM of the measurement of tissue saturation in oxygen (SmO2) by Near Infrared Spectrometry (NIRS) |
Countries
France
Contacts
Primary ContactElise ARTAUD-MACARI, MD
Backup ContactMaryline LEFORT
Outcome results
None listed