Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05372731

Enrollment

Registered

2022-05-13

Start date

2022-11-30

Completion date

2022-12-30

Last updated

2022-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome

Brief summary

ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.

Interventions

OTHERRecruitment Maneuver

RM after BAL

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adult patients with invasive mechanical ventilation; 2. Patients who diagnosed with ARDS according to the Berlin definition 3. There are indications for bronchoalveolar lavage

Exclusion criteria

1. Patients with contraindications for EIT procedures; 2. Patients with contraindications for RM; 3. Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD); 4. Pregnancy; 5. Refusal to sign informed consent

Design outcomes

Primary

Measure	Time frame	Description
the ratio of tidal volume in the BAL side and the other side	up to 24 hours	distribution of tidal volume monitored by electrical impedance tomography from the BAL side to the other side

Secondary

Measure	Time frame	Description
partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio	up to 24 hours	partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio
respiratory system compliance (the tidal volume to the driving pressure ratio)	up to 24 hours	respiratory system compliance was calculated by dividing expiratory tidal volume by the driving pressure (plateau pressure minus positive end-expiratory pressure)

Contacts

Primary Contactling liu, phD

liulingdoctor@126.com86-25-83272201

Backup Contactling liu, phD

86-25-83272201

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026