Healthy
Conditions
Brief summary
The project aims to evaluate the glycaemic index of breads from different types of flour. In particular, we aim to understand the glycaemic and insulin responses as well as satiety and sensory profiles of the products.
Interventions
OTHERStandard white bread
Bread to be consumed within 10 minutes after 10h fasting
OTHERExperimental white bread
Bread to be consumed within 10 minutes after 10h fasting
OTHERStandard High-fiber bread
Bread to be consumed within 10 minutes after 10h fasting
OTHERExperimental High-fiber bread
Bread to be consumed within 10 minutes after 10h fasting
Sponsors
Institut Polytechnique UniLaSalle
Paulic Meunerie SA
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Latin square randomization for test products following reference treatment (as per standard protocol)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Having a Body Mass Index (BMI) between 18.5 and 30 kg/m² * Non-smoker for more than three months * Having signed the informed consent form * Likely to follow the constraints generated by the study (one morning per week for 9 weeks) * Social insurance
Exclusion criteria
* Pregnant woman * Subject with a known progressive somatic or psychiatric disease * Fasting blood glucose greater than 6.1 mmol/L (1.10 g/L), postprandial blood glucose greater than 7.7 mmol/L (1.4 g/L) or known diabetes treated or untreated * Hyperinsulinemia or a history of insulinoma * HbA1c greater than 7 % * History of hypercholesterolemia, hypertension, diabetes or glucose intolerance * History of food allergy or digestive pathology likely to affect digestion or absorption * Renal failure * ASAT or ALAT elevation beyond 1.5 times the upper limit * Subject consuming more than three glasses per day of alcohol or suffering from various addictions * Weight change of more than 3 kg in the last three months * Person participating in another clinical study, or in a period of exclusion from another study * Person deprived of liberty or under judicial protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycaemic index | glycemia measured over 120 minutes | percentage area under the curve compared to standard white bread as 100% reference |
Countries
France
Outcome results
None listed