Collecting Ducts Carcinoma: in Depth Exploration and Biologically Driven Therapy (CICERONE)

Conditions

Collecting Duct Carcinoma

Brief summary

* Collect a large number of samples with certain / suspected diagnosis of collecting duct carcinoma in order to confirm the diagnosis (centralized review) and standardize according to WHO 2016 criteria * Build an extensive tissue bank (DNA and RNA extraction) aimed at defining the molecular taxonomy of the tumor through 1) transcriptomic analysis 2) gene expression profile * Define specific molecular signatures

Rametta A, Stellato M, Rota S, Gusmaroli E, Huber V, Gobbo S, Pedron S, Colombo P, Caliò A, Martignoni G, de Braud F, Procopio G, Brunelli M, Verzoni E.

2026-07-29

10.1016/j.esmoop.2026.108327

Nectin-4 and Trop-2 expression as potential therapeutic target in collecting duct carcinoma: Preliminary results from the CICERONE trial (NCT05372302).

Giuseppe Procopio, Alessandro Rametta, Marco Stellato, Filippo de Braud, Katia Todoerti et al. (18 authors)

Journal of Clinical Oncology2025-02-10

10.1200/jco.2025.43.5_suppl.587

Collecting ducts carcinoma: In depth exploration and biologically driven therapy (CICERONE).

Elena Verzoni, Filippo de Braud, Alessandro Rametta, Ida Taglialatela, Valentina Guadalupi et al. (17 authors)

Journal of Clinical Oncology2023-02-20

10.1200/jco.2023.41.6_suppl.tps754

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

No

Inclusion criteria

* Age ≥ 18 years * Signature of consent (for patients enrolled in the prospective part of the study) * Histological diagnosis of renal cell carcinoma of the Bellini collecting duct RCC

Exclusion criteria

\-

Design outcomes

Primary

Measure	Time frame	Description
samples to confirm and standardize	15 month	Collect a large number of samples with certain / suspected diagnosis of collecting duct carcinoma in order to confirm the diagnosis (centralized review) and standardize it according to WHO 2016 criteria

Secondary

Measure	Time frame	Description
Tissue Bank	15 month	Build an extensive tissue bank (DNA and RNA extraction) aimed at defining the molecular taxonomy of the tumor through 1) transcriptomic analysis 2) gene expression profile
specific molecular signatures	15 month	Define specific molecular signatures

Countries

Italy

Contacts

Primary ContactElena Verzoni, MD

elena.verzoni@istitutotumori.mi.it0223904449

Backup ContactRoberta Mennitto, Dr.ssa

roberta.mennitto@istitutotumori.mi.it0223903884

Outcome results