Chronic Lymphocytic Leukemia
Conditions
Brief summary
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder that is characterized by heterogeneous presentation at the clinical and molecular levels. ITGA4 protein has been found to be deregulated in CLL with adverse clinical outcome. ITGA4 gene (CD49d) encodes a member of the integrin alpha chain family of proteins and is considered a negative prognosticator in CLL with aggressive course and short time to treatment. The aim of the study: is to investigate ITGA4 gene expression pattern in CLL.
Interventions
None listed
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with newly diagnosed CLL.
Exclusion criteria
* ▪ Patients previously diagnosed as CLL and received treatment before. * Patients with other solid tumors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ITGA4 gene expression pattern in chronic lymphocytic leukemia | 1 year following the startpoint of the study | Detection of ITGA4 gene expression in blood samples in patients with chronic lymphocytic leukemia, Briefly, total RNA and genomic DNA extraction from fresh peripheral blood samples by Real-time -RT-polymerase chain reaction system (RT-PCR) will be carried out. Rate of ITGA4 gene expression will be recorded. |
Countries
Egypt
Contacts
Primary ContactAmer Ahmed Youssif
Outcome results
None listed