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BFR in Overweight Sedentary Subjects

Effects of a Physical Activity Program With Partial Vascular Occlusion on Body Composition, Biomechanics and Walking Energy in Overweight Sedentary Subjects

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05371119
Enrollment
30
Registered
2022-05-12
Start date
2022-02-01
Completion date
2022-04-15
Last updated
2022-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight

Keywords

blood flow restriction

Brief summary

This project should allow the investigators to observe the effects of low load training under partial vascular occlusion (BFR) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. Training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a classic type training with heavy loads. Thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

Detailed description

The main objective of this study is to observe the effects of low load training under vascular occlusion (BFR) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients. 3.2 Primary and secondary endpoints The first hypothesis is that the BFR drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns. The second hypothesis is that BFR training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. In addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol. 3.3 Study design This single-center project aims to test the effects of low-load training under partial vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion in overweight sedentary people. The main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. This project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

Interventions

OTHERExercise Intervention

Training with light load with blood flow restriction (BFR)

Sponsors

University of Lausanne
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Masking description

BFR inflated 20 mmHg

Intervention model description

The procedure will consist of 6 weeks of training with or without partial vascular occlusion (depending on group A or group B) at the rate of 3 sessions per week (for a total of 18 training sessions).

Eligibility

Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* IMC between 25 and 35 * vaccin against Covid-19

Exclusion criteria

hypertension diabete

Design outcomes

Primary

MeasureTime frameDescription
DEXA technologyOne week before interventionBody composition assessment: relative lean and fat mass in all body segments
Evaluation of muscle strength from an isokinetic deviceOne week before interventioneccentric and concentric peak torque of the knee extensor muscles
Evaluation of the preferential speed of walking in an ecological situationOne week before interventionnusing of a treadmill with measurement of the ground reaction forces
Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.One week before interventioncalculation of the mechanical work
Evaluation of the energy cost of walkingOne week before interventionon a treadmill, by indirect calorimetry with gaz exchanges

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 10, 2026