Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes

Association of Coronary Artery Disease With Lewis and ABO Blood Group Phenotypes- A Case Control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05369702

Enrollment

210

Registered

2022-05-11

Start date

2019-11-01

Completion date

2021-04-30

Last updated

2022-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

ABO blood group system, Lewis negative phenotype, coronary artery disease

Brief summary

Primary objective- To study the association of Lewis antigen and A, B, O blood group phenotypes with coronary artery disease patients attending the tertiary care hospital in Kerala. The secondary objective-To find the association of Lewis antigen and A, B, O blood group phenotypes with smoking, alcohol use, diabetes, hypertension and dyslipidemia. A case-control study to compare the prevalence of Lewis(a-b-) blood group among confirmed cardiac cases with the prevalence of the same among the general population and thereby find out if individuals with Lewis(a-b-) are more at risk of developing coronary artery disease. This may provide an economical and simple method for identifying subjects at increased risk for coronary artery disease and subsequently lead to more focused preventive measures and eventually to a specific treatment.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

\- Patients in the age group of 30-55 years at the time of data collection diagnosed with coronary artery disease based on positive changes in coronary angiogram (more than 70% coronary stenosis)

Exclusion criteria

* Patients with other systemic illnesses like malignancy, autoimmune diseases. * Patients who were not willing to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of Lewis and ABO blood group phenotypes in cases and controls.	Lewis and ABO phenotype of the study participants was determined immediately after sample collection	Prevalence Lewis and ABO phenotype in cases will be compared to prevalence of the same in controls.

Countries

India

Outcome results