Prognosis, Radiomics, Spinal Tumor, Stereotactic Radiosurgery
Conditions
Brief summary
This study aims to assess multimodal Radiomics-based prediction model for prognostic prediction in spinal tumors.
Detailed description
Sensitivity for prediction recurrence and survival of currently available prognostic scores is limited. This study proposes to establish a multimodal radiomics model for identifying tumor recurrence and prognostic prediction of spinal tumors. The study will investigate the relationship between the radiomics and the tumor microenvironment. The study includes the construction of multimodal radiomics-based prediction model and the validation of the prediction model.
Interventions
OTHERNo interventions
As this is a prognosis evaluation study, there are no interventions.
Sponsors
Zhuang Hongqing
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
A diagnosis of spinal tumors for which SBRT is appropriate Karnofsky Performance Status \>60 Life expectancy of at least 3 months No contraindication to undergoing MR imaging Age \>18 Complete the CT MRI or PET-CT examination before and after treatment Accept stereotactic radiosurgery
Exclusion criteria
Subjects unable to undergo MRI (includes non-MRI compatible material or devices and severe claustrophobia) Subjects with prior procedural intervention to the involved vertebral body that would result in artifact (kyphoplasty, screw and/or rod placement); minimally invasive surgery without instrumentation of the involved vertebral body and instrumentation immediately above or below the index lesion is allowed. Subjects with spinal cord compression; minimally invasive separation surgery to first resect the epidural component is allowed Pregnant or breast-feeding women Allergy to standard IV contrast agents used in MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PFS | 1 years | progression-free survival |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival (OS) | 1 years | defined as the time from the beginning of diagnosis of spinal tumors to the death with any causes |
| ORR | 3 months | objective response rate |
| DCR | 3 months | disease control rate |
| Recurrence free survival (RFS) | 1 year | defined as time between randomization and the time of any recurrence of ipsilateral chest, breast, regional lymph node recurrence, distant metastases, or death occurred |
Countries
China
Contacts
Primary ContactHongqing zhuang
Backup ContactMingqing Wang
Outcome results
None listed