Non-cystic Fibrosis Bronchiectasis, Pulmonary Rehabilitation
Conditions
Brief summary
A number of studies have described low exercise capacity and physical activity in patients with non-cystic fibrosis bronchiectasis (non-CF Bronchiectasis), although little research exists on using the cardiopulmonary exercise test (CPET) to evaluate exercise capacity and its most relevant changes after a pulmonary rehabilitation home-based program (PRHP). In addition, few studies have addressed tolerance to exercise and physical activity in severe cases of the disease. Aims: To evaluate the exercise capacity of non-CF BQ patients using CPET and physical activity after a pulmonary rehabilitation home-based program. Methodology: Our study describes a non-pharmacological clinical trial in non-CF BQ patients at the Virgen Macarena University Hospital (Seville, Spain). The patients were randomized into two groups: the control group (who were provided with training instructions) and the intervention group (who took part in a specific pulmonary rehabilitation home-based program).
Detailed description
A signed informed consent form was provided prior to inclusion in the study. The data evaluated was obtained under strict confidentiality rules. All patients passed an initial assessment of the degree of physical activity by means of accelerometers, as well as pulmonary function tests and exercise tolerance (CPET) and 6MWT, stratification severity according to the E-FACED scales, quality of life using the saint george respiratory questionnaire.
Interventions
OTHERPulmonary rehabilitation home-based program intervention group (PRHP)(IG)
The strength training program included upper and lower limb exercises, initially with no weights but progressively adding weights once a week depending on symptoms, in 2 sets with 6-8 repetitions, for at least 5 days a week. The exercises recommended were the 'hanger' (which exercises the latissimus dorsi muscle), 'butterfly' (pectoralis major muscle), 'neck press' (triceps brachii and deltoids), leg flexion (biceps femoris and gastrocnemius) and leg extension (quadriceps femoris). As resistance training, patients could choose between walking or cycling 3 to 5 days per week, for at least 20 minutes, increasing the duration of the exercise weekly, depending on their symptoms
Sponsors
Hospital Universitario Virgen Macarena
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Clinical trial with parallel groups (Parallel treatment design): Clinical trial in which one group of patients is assigned to receive the home pulmonary rehabilitation program (PHRP), while another group (control) does not receive PHRP
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Certain diagnosis of non-CF bronchiectasis (chest HRCT) * Over 18 years old, clinically stable in the previous 6 weeks (no need for antibiotic therapy due to exacerbations) and a dyspnea score over 1 according to the modified Medical Research Council (mMRC) dyspnea scale
Exclusion criteria
* Less of 18 years * Other airway disease ( Asthma or COPD) * Physical inability to perform a physical training program (neuromuscular pathology or residual injuries). * Smokers or former smokers of less than 6 months or with a history of consumption of 15 packs/year. * Cystic fibrosis. * Active infections (bronchopulmonary aspergillosis, pulmonary tuberculosis). * Active tuberculosis. * Medical illnesses that put the individual at risk of a decompensation due to the performance of any physical activity or cardiopulmonary stress test (unstable ischemic heart disease, acute myocardial infarction less than 1 month). * Pregnancy * Mental disorder that prevents the adequate interpretation of the indications or performance of the tests. * Attended pulmonary rehabilitation within 1 year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise capacity of Non-cystic Fibrosis Bronchiectasis ( Non-CF bronchiectasis) after pulmonary rehabilitation home-based program (PRHP). Change in VO2 (oxygen consumption, ml/min) | Baseline and week 8 | A measurement by cardiopulmonary exercise test (CPET) with oxygen consumption was performed at baseline and week 8 of the program. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of physical activity (METS) of Non-CF bronchiectasis and its changes after PRHP | Baseline and week 8 | Change in level of physical activity assessed using a Multisensor ArmBand accelerometer (METS). |
| Impact of quality of life before and after PRHP | Baseline and week 8 | Change in St. George's Respiratory Questionnaire (SGRQ) after PRHP: Have 50 items with 3 components Symptoms, Activities, Impact ant total score. Scores range from 0 to 100, with higher scores indicating more limitations. |
| Dyspnoea | Baseline and week 8 | Change in dyspnoea by modified Medical Research Council (MRC) |
| Exacerbations | Baseline, week 4 and week8 | Numbers of Hospital admissions in previous month |
| Level of physical activity (number of steps) of Non-CF bronchiectasis and its changes after PRHP | Baseline and week 8 | Change in level of physical activity assessed using a Multisensor ArmBand accelerometer (number of steps). |
Countries
Spain
Outcome results
None listed