Pulmonary Arterial Hypertension
Conditions
Brief summary
This is a observational、multicenter, prospective cohort study for patients with pulmonary hypertension (PH). The purposes of this study were to evaluate the etiology、clinical characteristics、treatment modalities, and outcomes of patients with PH；also to set up registration system of PH in China, to build a database of Chinese PH, to establish a web-based international standard data acquisition system for PH and a multicenter clinical research platform. The results of the study will provide a basis for the future national health policy for prevention and treatment of PH.
Interventions
COMBINATION_PRODUCTThe clinical course and disease management
The clinical course and disease management of pulmonary hypertension patients
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Newly diagnosed or previously diagnosed patients with PH. * Documentation of mean pulmonary arterial pressure (mPAP) \>20 mm Hg by right heart catheterization, performed at any time prior to study enrollment.
Exclusion criteria
* Have not had documentation of hemodynamic criteria for PH by right heart catheterization at some time preceding study entry and following development of symptoms associated with PH. * Do not meet the required hemodynamic criteria for entry into the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause Death | 5 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Clinical Worsening | 5 years | Clinical worsening during follow-up was defined as worsening PAH or atrial septostomy or listing for lung transplantation or all-cause death. Worsening PAH required the presence of worsening PAH symptoms and a decrease in 6-minute walk distance greater than 15% from baseline and the requirement for additional PAH treatments (all three conditions had to be present). |
Countries
China
Contacts
Primary ContactShao-Liang Chen, MD, PhD
Backup ContactJing Kan, MPH
Outcome results
None listed