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GATT Versus Canaloplasty (GVC)

Longterm Comparison of Gonioscopy-assisted Transluminal Trabeculotomy and Canaloplasty in Open-angle Glaucoma Treatment

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05366647
Enrollment
100
Registered
2022-05-09
Start date
2022-06-01
Completion date
2025-06-01
Last updated
2025-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Open-Angle

Keywords

Gonioscopy-assisted Transluminal Trabeculotomy, Canaloplasty, Glaucoma

Brief summary

Study aims to compare the effectiveness and safety profile of Gonioscopy-assisted Transluminal Trabeculotomy and canaloplasty, in order to find out if one operation is superior to the other. Both procedures are performed in patients with medically uncontrolled open-angle glaucoma. Canaloplasty is a recently newly introduced procedure, which showed encouraging results without antimetabolite usage intra- and postoperatively. Gonioscopy-assisted Transluminal Trabeculotomy is the procedure that aims the same mechanism of aqueous outflow, however is perform with ab interno approach, which comprise it to the minimally invasive glaucoma surgery techniques. Purpose of the study is to compare both surgeries concerning success rate, intraocular pressure, medication burden and complications rate. So far there is no comparison of the Gonioscopy-assisted Transluminal Trabeculotomy and canaloplasty available.

Interventions

PROCEDUREcanaloplasty

canaloplasty ab interno with tensioning suture

PROCEDUREGonioscopy-assisted Transluminal Trabeculotomy

Gonioscopy-assisted Transluminal Trabeculotomy ab interno

Sponsors

Medical University of Lublin
CollaboratorOTHER
Medical University of Bialystok
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18 Years and older (Adult, Older Adult) * patients with confirmed uncontrolled open angle glaucoma * no prior glaucoma surgery (once laser trabeculoplasty or cyclophotocoagulation) allowed

Exclusion criteria

* angle closure glaucoma * congenital glaucoma * inflammatory glaucoma

Design outcomes

Primary

MeasureTime frameDescription
success rate (complete and qualified success)12 monthsSuccess is defined: 1. IOP \< 21 mmHg and at least 20% IOP change from baseline 2. IOP \< 18 mmHg

Secondary

MeasureTime frameDescription
IOP, medication, complications12 monthsintraocular pressure change, medication postoperatively, complications intra- and postoperatively

Countries

Poland

Contacts

Primary ContactJoanna Konopińska
joannakonopinska@o2.pl+48600471666
Backup ContactEwa Kosior-Jarecka
ekosior@poczta.onet.pl

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026