Monogenic Obesity
Conditions
Keywords
monogenic obesity, pediatric, early onset obesity, genetic disease
Brief summary
Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene (monogenic obesity). The diagnosis of these rare forms can lead to personalized management (new treatments, prognosis, adapted hygienic and dietary rules) and family screening. The use of a panel covering the known causes of monogenic obesity on a pediatric cohort of severe and early obesity will allow to evaluate the relevance of these analyses to adapt the management of this type of patients.
Interventions
BIOLOGICALSalivary Sampling
The DNA study will be carried out from saliva sample 1 saliva sample per patient will be performed at the inclusion visit
Sponsors
University Hospital, Bordeaux
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* Recruitment age: 2-17 years * Body mass index, greater than the International Obesity Task Force (IOTF) 30 curve before the age of 5 * Care at the specialized pediatric obesity center (CSO) of the Bordeaux University Hospital * Informed consent signed
Exclusion criteria
* no informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positivity rate of patients for whom a diagnosis of monogenic obesity will be obtained when all analyses have been performed. | Inclusion visit |
Secondary
| Measure | Time frame |
|---|---|
| Number of Patients eligible for a drug targeting single-gene obesity | Inclusion visit |
| Number of patients for whom a genetic finding will have changed management and description of changes. | Inclusion visit |
Countries
France
Contacts
Primary ContactLouis LEBRETON
Backup ContactWafae BELCADI
Outcome results
None listed