Analgesia
Conditions
Brief summary
This study aims to compare single level serratus block versus bilevel serratus block with and without dexmedetomidine in cancer patients undergoing modified radical mastectomy for breast cancer regarding pain control and possible side effects.
Interventions
PROCEDURESingle level serratus anterior plane block
Serratus anterior plane block with local anesthetics at the third rib
PROCEDURESingle level serratus anterior plane block with dexmedetomidine
Serratus anterior plane block with local anesthetics and dexmedetomidine at the third rib
PROCEDUREBilevel serratus anterior plane block
Serratus anterior plane block with local anesthetics at the third and fifth rib
PROCEDUREBilevel serratus anterior plane block with dexmedetomidine
Serratus anterior plane block with local anesthetics and dexmedetomidine at the third and fifth rib
Sponsors
National Cancer Institute, Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients scheduled for modified radical mastectomy, * Age 18-65 years, * ASA I-II
Exclusion criteria
* patient refusal, * coagulation defects, * abnormal kidney or liver functions, * local infection at site of injection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| First time to receive analgesia | First 24 hours postoperatively | first time to receive morphine analgesia in hours |
| Total analgesic requisite | First 24 hours postoperatively | total amount of morphine consumption in the first 24 hours postoperatively in mg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain scores | First 24 hours postoperatively | pain scores will be assessed using Visual Analogue Scale on a sale from 0 to 10 with 0 meanung no pain and 10 meaning severe pain |
| Side effects | First 24 hours postoperatively | nausea and vomiting and hematoma at site of injection |
| Perioperative heart rate values | First 24 hours | heart rate values in the form of beat per minute in the perioperative period including preoperative, intraoperative and postoperative |
| Mean arterial blood pressure | First 24 hours | Mean arterial blood pressure values in the form mmHg in the perioperative period including preoperative, intraoperative and postoperative |
Countries
Egypt
Contacts
CONTACTWalaa Y Elsabeeny, MD
CONTACTNahla N Shehab, MD
PRINCIPAL_INVESTIGATORWalaa Y Elsabeeny, MD
Assistant Professor of Anesthesia and Pain management
Outcome results
None listed