Pulpitis - Irreversible
Conditions
Brief summary
This randomized, double-blind clinical trial aimed at the evaluation of the effect of adding dexamethasone to 2% lidocaine, given as inferior alveolar nerve block in the endodontic management of symptomatic irreversible pulpitis. One hundred and twenty four patients received one of the three IANB injections before the endodontic treatment: 2% lidocaine with 1:80 000 epinephrine; 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone; and plain 2% lidocaine mixed with 2mg dexamethasone. The anesthetia was considered successful if the patients experienced no pain or faint/weak/mild pain during root canal access preparation and instrumentation (HP VAS score \<55 mm). The effect of intraligamentary injections on maximum heart rates was also recorded.
Interventions
DRUGLidocaine Hydrochloride
Inferior alveolar nerve block
Sponsors
Jamia Millia Islamia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
Yes
Inclusion criteria
* absence of any periapical radiolucency on radiographs, except for a widened periodontal ligament * active pain in a mandibular molar * prolonged response to cold testing with an ice stick and an electric pulp tester * vital coronal pulp on access opening and ability to understand the use of pain scales
Exclusion criteria
* a history of known or suspected drug abuse * history of active peptic ulcer within the preceding 12 months * history of bleeding problems or anticoagulant use within the last month * known allergy, sensitivity, or contraindications to any opioid or nonopioid analgesic including aspirin or NSAIDs * patients who had taken NSAIDs within 12 h before administration of the study drugs * patients who were pregnant or breast-feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anesthtic success | 15 minutes after the inferior alveolar nerve block | Pain during the endodontic treatment was assessed using a visual analog scale (Heft-Parker VAS). Success was defined as no or mild pain (pain score≤54mm on Hp VAS) during access preparation and root canal instrumentation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart Rate | After 1 minutes of initial injection | The effect of injections on maximum heart rates was recorded. |
Countries
India
Outcome results
None listed