Fluid Management
Conditions
Keywords
Stroke volume variation, Fluid therapy, Hepatectomy, Alanine aminotransferase, Estimated glomerular filtration rate
Brief summary
Studies have demonstrated that the rate of change in stroke volume variation (SVV) can be used to determine the volume of body fluids during major abdominal surgery. Anaesthesiologists can use SVV as a guide for the appropriate administration of intraoperative fluids to improve postoperative prognoses. Liver surgery is a major abdominal operation, and the amount of blood lost is typically higher than that during other general abdominal surgeries. Blood loss is positively correlated with the intraoperative fluid infusion volume, and greater blood loss is associated with more postoperative complications. Additionally, comorbid liver disease or cirrhosis can increase the complexity of liver tumour resection, causing difficulty in assessing intravascular volume and determining the appropriate intraoperative infusion volume.
Interventions
PROCEDURESVV-guided fluid management
fluid will be guided by value of stroke volume variation
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
This trial had a randomised study design with simple randomisation and a fixed allocation ratio (1:1 to the low-SVV group or high-SVV group). The patients were blinded to the randomisation and allocation.
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* We initially selected 118 patients who required hepatectomy. * The physiological status of the patients was assessed in terms of American Society of Anesthesiologists scores I-III
Exclusion criteria
* Extreme body mass index (BMI) * Age under 20 or over 75 years * Emergency surgery * Preexisting cardiac, hepatic, renal, or coagulation disorder; hyperthyroidism; and sinus arrhythmia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of postoperative complications in the two groups. | From day 1 to day 30 after surgery. | calculate the incidence of postoperative complication within 30 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The differences of perioperative ALT | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
| The differences of perioperative eGFR | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
| The differences of perioperative creatinine | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
| The pain scale | up to three days postoperatively | Assessment of postoperative pain scale |
| The differences of perioperative Hb | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
| The differences of perioperative arterial lactate | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
| The differences of perioperative albumin | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
| The differences of perioperative T.bil | Examination report on the 1st postoperative day. | Calculate the difference of the perioperative physiological variables |
Countries
Taiwan
Outcome results
None listed